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Literature

So far, more than 260 peer reviewed papers have been published on the application of DryLab – a complete list of which you can find here.

DryLab draws on the philosophy described in the three most famous Solvophobic Theory papers I, II, III of Csaba Horváth, which were developed in the years 1975-1977 at Yale University (see also literature by Dr. Imre Molnár).

Read more about the Fundamentals of DryLab and its History.

Keyword Year

Enantioselective multiple heart cutting online two-dimensional liquid chromatography-mass spectrometry of all proteinogenic amino acids with second dimension chiral separations in one-minute time scales on a chiral tandem column

Ryan Karongo, Min Ge, Christian Geibel, Jeannie Horak, Michael Lammerhofer
Analytica Chimica Acta, 1180, 2 October, 1-13 (2021)

Keywords: Two-dimensional liquid chromatography, UHPLC, Multiple heart-cutting, Enantioselective amino acid separation, L-[u-13C15N] amino acid internal standard

PDF
http://doi.org/10.1016/j.aca.2021.338858

Highlights

  • Multiple heart cutting 2D LC-MS for enantioselective amino acid (AA) analysis (AQC derivatized).
  • 1D achiral RP separation of proteinogenic AAs and isobaric analogues of (aIle, Nle, Tle; Hse, aThr).
  • 2D chiral separations of 24 amino acids achieved on a chiral tandem column in 68 s.
  • Use of time-based sampling, smart peak parking and shifted gradient tool for efficient analysis.
  • Fastest 2D-LC separation for enantioselective amino acid analysis to date (in total 45 min).

 

Simultaneous determination of loading capacity and selectivity in preparative off-line two-dimensional separation: An application for purification of corilagin from Pomegranate flower extracts

Guliqire Adili et. al
Journal of Chromatography A, 1622, 1-9 (2020)

Keywords: Capacity orthogonal chromatography, Two-dimensional separation, Loading capacity, Orthogonality, Corilagin pomegranate flower extract

PDF
http://doi.org/10.1016/j.chroma.2020.461129

Highlights:

  • New method of 2D separation was developed with a use of HPLC-MS and DryLab software.
  • The method could optimize orthogonality and loading capacity simultaneously.
  • Theoretical fundamental and practical terms of the new method were discussed.
  • The method was used to purity 228 mg corilagin from pomegranate flower extracts.

 

High-performance liquid chromatography (HPLC)-fluorescence method for determination of bisphenol A diglycidyl ether (BADGE) and its derivatives in canned foods

Mingming Guo, Mingfeng He et al.
Science of The Total Environment, 710, 1-8 (2020)

Keywords: Bisphenol A diglycidyl ether (BADGE), HPLC, Core–shell particle column, Canned foods

PDF
http://doi.org/10.1016/j.scitotenv.2019.134975

Highlights:

  • HPLC-FLD method for BADGE and its derivatives analysis with LOD of 0.01–0.20 ng/g.
  • The optimization of separation conditions applying DryLab® software.
  • Adequate separation in 5 min using a core–shell particle column.

 

 

Improving selectivity and performing online on-column fractioning in liquid chromatography for the separation of therapeutic biopharmaceutical products

Sz. Fekete, H. Ritchie, J. Lawhorn, J.-L. Veuthey, D. Guillarme
Journal of Chromatography A, 1618, 1-9 (2020)

Keywords: Column coupling, Fractioning, Biopharmaceuticals, Mab, Improving selectivity

PDF
http://doi.org/10.1016/j.chroma.2020.460901

Highlights:

  • A novel column-coupling approach is suggested for large solute separations.
  • Widepore columns of different retentivity were selected for the coupling.
  • The suggested approach improves both the selectivity and efficiency.
  • The parameters of the linear solvent strength models were obtained using DryLab software. 
  • On-column protein fractioning can be rapidly performed.

 

 

Development of a generic reversed-phase liquid chromatography method for protein quantification using analytical quality-by-design principles

Julian Kopp et al.
Journal of Pharmaceutical and Biomedical Analysis, 188, 1-9 (2020)

Keywords: Liquid chromatography, (U)HPLC, Protein quantification, E. coli, Analytical quality by design (AQbD), Design of Experiment (DoE)

PDF
http://doi.org/10.1016/j.jpba.2020.113412

Highlights:

  • DryLab Assisted modeling of secondary method factors.
  • Timely and accurate analytics needed for recombinant protein production.
  • Chromatographic modeling accelerated method development using an AQbD approach.
  • Robustness of Method Operable Design Region tested in-silico and experimentally.
  • Developed RPLC-Method is superior to current analytical techniques.

 

Updating the European Pharmacopoeia impurity profiling method for terazosin and suggesting alternative columns

D. Enesei, I. Kapui, Sz. Fekete, R. Kormány
J. Pharm. Biomed. Anal., 187, 1-10 (2020)

Keywords: Column comparison, Design of experiments, Method validation, Quality by design, Robustness, Terazosin

PDF
http://doi.org/10.1016/j.jpba.2020.113371

Highlights:

  • A new (U)HPLC method was developed for terazosin impurity profiling with DryLab to update the Ph. Eur. Method.
  • A generic workflow has been proposed to suggest replacement columns for a given separation.
  • Column comparison was based on the visualization and overlay of design spaces.
  • The new method was validated in accordance with international guidelines.

 

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