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Literature

So far, more than 270 peer reviewed papers have been published on the application of DryLab – a complete list of which you can find here.

DryLab draws on the philosophy described in the three most famous Solvophobic Theory papers I, II, III of Csaba Horváth (Tribute to Cs. Horváth), which were developed in the years 1975-1977 at Yale University (see also literature by Dr. Imre Molnár).

Read more about the Fundamentals of DryLab and its History.

 

Keyword Year

A novel 3D-printed sample preparation method for benzodiazepine quantification in human serum

Dagmara Kroll et. al
Analytica Chimica Acta, 1337, 1 February, 1-8 (2025)

Keywords: Benzodiazepines, 3D printing, Solid-phase microextraction, Sample preparation, Fused deposition modelling, Human serum

PDF
http://doi.org/10.1016/j.aca.2024.343552

Highlights

  • Extraction utilizing 3D-printed sorbent devices.
  • Devices made with a thermoplastic material with incorporated C18 silica.
  • Sample preparation fully validated in human serum according to ICH guideline.
  • A DryLab optimized LC-MS method for separation of 11 benzodiazepines.
  • A protocol suitable for toxicological and medical analyses of real samples.

 

Leveraging Multidimensional Modeling to Resolve Frequent Separation Challenges in HPLC

Arnold Zoldhegyi, Róbert Kormány, Szabolcs Fekete, Krisztián Horváth, Imre Molnár
Column, 21, 3, 14-20 (2025)

http://www.chromatographyonline.com/view/levera...

Highlights

  • Gas chromatography and HPLC modeling have evolved, providing diverse tools for method development and chromatographic behavior prediction.
  • Empirical DoE and first-principles approaches offer distinct advantages in method development, with multidimensional models enhancing pharmaceutical research.
  • Design space comparison tools address challenges like column interchangeability, batch-to-batch reproducibility, and system comparisons, supporting robust HPLC analysis.
  • Recent studies highlight the importance of systematic modeling approaches in addressing practical challenges in routine analytical work.

Case Study: Robustness Investigations

Gerd Kleinschmidt, Birgit Niederhaus
Method Validation in Pharmaceutical Analysis, Joachim Ermer, Phil Nethercote, (Wiley‐VCH GmbH, 3, 2025), 301-341 / Chapter 11

http://doi.org/10.1002/9783527831708.ch11

Linear solvent strength model on porous graphitic carbon stationary phase using high temperature liquid chromatographic method for allopurinol related substances analysis

Barnabás Soós, Krisztián Horváth, Róbert Kormány
Journal of Pharmaceutical and Biomedical Analysis, 245, 1 August, 1-6 (2024)

Keywords: Allopurinol, High temperature liquid chromatography, Porous graphitic carbon, DryLab, Method development, Retention modeling

http://doi.org/10.1016/j.jpba.2024.116200

Highlights 

  • Allopurinol and its Ph.Eur. impurities are analyzed with porous graphitic carbon.
  • The retention behavior is different than in reversed phase separations.
  • Linear solvent strength (LSS) theory can be used for method development.
  • All compounds can be separated in 6 min with baseline resolution.
  • LSS-based method development software are efficient for PGC phases.

 

Application of chiral stationary phases for the separation of vitamin A acetate isomers

Nicole Schräder et. al
Journal of Chromatography A, 1718, 15 March, 1-8 (2024)

Keywords: Chiral stationary phases, High performance liquid chromatography, Vitamin A acetate isomers, Cellulose stationary phases, Amylose stationary phases

PDF
http://doi.org/10.1016/j.chroma.2024.464710

Highlights 

  • Vitamin A isomer separation in RP mode on CSPs is superior to existing methods.
  • Screening of CSPs provides ideal stationary phase.
  • Molecular planarity recognition is the predominant retention mechanism.
  • Method optimization and considerations for a better suited stationary phase design.

 

Revisiting column selectivity choices in ultra-high performance liquid chromatography–Using multidimensional analytical Design Spaces to identify column equivalency

Arnold Zöldhegyi, Krisztián Horváth, Róbert Kormány
Journal of Chromatography A, 1719, 29 March, 1-10 (2024)

Keywords: Analytical quality by design, Method operable design region, Replacement columns, Design space modeling, Qualifying similarity/orthogonality in HPLC

PDF
http://doi.org/10.1016/j.chroma.2024.464738

Highlights 

  • Introducing modeling methodology for a robust assessment of UHPLC column provided selectivities.
  • Multidimensional Design Spaces offering AQbD-compliant alternative for column selectivity testing and comparison methods.
  • Identifying shared method conditions with established interchangeability between various C18 stationary phases.
  • Pharmaceutical application: optimal workpoints, substitute columns, ensure consistency, identification of equivalent/orthogonal column selectivities.  

 

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