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Literature

So far, more than 260 peer reviewed papers have been published on the application of DryLab – a complete list of which you can find here.

DryLab draws on the philosophy described in the three most famous Solvophobic Theory papers I, II, III of Csaba Horváth, which were developed in the years 1975-1977 at Yale University (see also literature by Dr. Imre Molnár).

Read more about the Fundamentals of DryLab and its History.

Keyword Year

Extended multidimensional design space studies: Comparing volatile and non-volatile buffer systems in UPLC

Arnold Zöldhegyi, Barnabás Soós, Krisztián Horváth, Imre Molnár, Róbert Kormány
Journal of Chromatography A, 1751, 21 June, 1-11 (2025)

Keywords: pH-selection in reversed phase chromatography, Volatile Non-volatile buffer interchangeability, Salting-out Effects, Analytical quality by design, Design space comparison

http://doi.org/10.1016/j.chroma.2025.465951

Highlights

  • Practical challenges of pH selection under reversed-phase conditions.   
  • Using Design Space modeling to capture dynamic separation behavior of volatile and non-volatile buffer systems.
  • Applying Design Space Comparison for in-depth buffer interchangeability studies.  
  • Research outlook: Selectivity differences observed with NH₄⁺, K⁺, Na⁺, and Li⁺ buffer cations, highlighting varying salting-out effects.

 

Weak to strong ion-pair gradients to expand the selectivity of oligonucleotide separations in reversed phase liquid chromatography - A proof of concept

Szabolcs Fekete, Mateusz Imiolek, Matthew Lauber
Journal of Chromatography Open, 7, May, 1-8 (2025)

Keywords: Ion-pair reversed phase chromatography, Oligonucleotide separation, Dual-gradient, Selectivity, Ultra-short column

PDF
http://doi.org/10.1016/j.jcoa.2024.100200

Highlights

  • A dual gradient approach is proposed to enhance the separation of oligonucleotides.
  • Running a weak to strong ion pair gradient significantly expands the elution window.
  • Combination of dual gradient with concave gradient program shows further benefits.
  • The degree of freedom can be significantly improved to extend the design space.

 

A novel 3D-printed sample preparation method for benzodiazepine quantification in human serum

Dagmara Kroll et. al
Analytica Chimica Acta, 1337, 1 February, 1-8 (2025)

Keywords: Benzodiazepines, 3D printing, Solid-phase microextraction, Sample preparation, Fused deposition modelling, Human serum

PDF
http://doi.org/10.1016/j.aca.2024.343552

Highlights

  • Extraction utilizing 3D-printed sorbent devices.
  • Devices made with a thermoplastic material with incorporated C18 silica.
  • Sample preparation fully validated in human serum according to ICH guideline.
  • A DryLab optimized LC-MS method for separation of 11 benzodiazepines.
  • A protocol suitable for toxicological and medical analyses of real samples.

 

Linear solvent strength model on porous graphitic carbon stationary phase using high temperature liquid chromatographic method for allopurinol related substances analysis

Barnabás Soós, Krisztián Horváth, Róbert Kormány
Journal of Pharmaceutical and Biomedical Analysis, 245, 1 August, 1-6 (2024)

Keywords: Allopurinol, High temperature liquid chromatography, Porous graphitic carbon, DryLab, Method development, Retention modeling

http://doi.org/10.1016/j.jpba.2024.116200

Highlights 

  • Allopurinol and its Ph.Eur. impurities are analyzed with porous graphitic carbon.
  • The retention behavior is different than in reversed phase separations.
  • Linear solvent strength (LSS) theory can be used for method development.
  • All compounds can be separated in 6 min with baseline resolution.
  • LSS-based method development software are efficient for PGC phases.

 

Computer-assisted multifactorial method development for the streamlined separation and analysis of multicomponent mixtures in (Bio)pharmaceutical settings

Mohamed Hemida, Imad A. Haidar Ahmad, Rodell C. Barrientos, Erik L. Regalado
Analytica Chimica Acta, 1293, 8 March, 1-15 (2024)

Keywords: Computer-assisted, Optimization, Liquid chromatography, Method development, Complex mixtures, (Bio)pharmaceuticals

PDF
http://doi.org/10.1016/j.aca.2023.342178

Highlights 

  • Computer-Assisted multifactorial chromatographic strategies were addressed.
  • Using proper linear and non-linear models were discussed.
  • Applications in various chromatographic techniques are critically reviewed.
  • Important parameters for retention mechanism modelling are demonstrated.
  • Computer-Assisted optimization strategies are highlighted for generic methods.

 

Application of chiral stationary phases for the separation of vitamin A acetate isomers

Nicole Schräder et. al
Journal of Chromatography A, 1718, 15 March, 1-8 (2024)

Keywords: Chiral stationary phases, High performance liquid chromatography, Vitamin A acetate isomers, Cellulose stationary phases, Amylose stationary phases

PDF
http://doi.org/10.1016/j.chroma.2024.464710

Highlights 

  • Vitamin A isomer separation in RP mode on CSPs is superior to existing methods.
  • Screening of CSPs provides ideal stationary phase.
  • Molecular planarity recognition is the predominant retention mechanism.
  • Method optimization and considerations for a better suited stationary phase design.

 

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