So far, more than 260 peer reviewed papers have been published on the application of DryLab – a complete list of which you can find here.
DryLab draws on the philosophy described in the three most famous Solvophobic Theory papers I, II, III of Csaba Horváth, which were developed in the years 1975-1977 at Yale University (see also literature by Dr. Imre Molnár).
Computer simulation was used to optimize high-performance liquid chromatography of phenol and its chloro and nitro derivatives. On the basis of two linear gradient runs of different steepness (RP-18—water + methanol + 1% acetic acid), several simulated gradient runs allowed the optimum gradient programme and flow-rate to be chosen so that the time of analysis could be considerably shortened. Good agreement between simulated and experimental chromatograms was obtained in spite of changes in experimental conditions.
Liquid Chromatography Expert Systems: A Modular Approach – Solvophobic Interactions Part III
Requirements for new pharmaceutical products and their impact on applications of high-performance liquid chromatography (HPLC) are discussed. The strengths and weaknesses of HPLC in this context are evaluated and compared with current trends and expectation in separation science.
Integration of Computer-Aided Method Development Techniques in LC
Computer-aided method development techiques have been commercially available for a number of years. Each of these procedures has strengths and weaknesses. In the past, hidden difficulties in the practical application of computeraided method development have discouraged their widespread use. This paper proposes the complementary use of these techniques so that their strengths are maximized while their weaknesses are compensated for. The result is a method development strategy that obtains simple solutions for simple separation problems and reserves the more complex solutions for difficult separations.