DryLab Training Courses

Molnár-Institute offers courses on the application of the DryLab software for efficient HPLC method development.  Our courses are taught by Dr. Imre Molnár, Dr. Hans-Jürgen Rieger, and guest lecturer Alexander H. Schmidt (founder and president of Chromicent GmbH), each of whom bring in-depth knowledge and experience to the classroom in both theory and practice of HPLC.  

Courses are taught in English regularly throughout the year in Berlin, and we also offer In-House courses in English or German at company locations worldwide. Please contact us for more information.


Intensive DryLab®4 Training for UHPLC Method Development – 3 Days

This course provides extensive training for the UHPLC method development by modeling under the use of the software DryLab4. Course participants are guided through a comprehensive method development process, starting with basic one-dimensional model calculations and continuing through multi-dimensional (3D) model optimizations. Users learn to develop, adjust, transfer, and improve methods, focusing on decreasing run times while maintaining the desired selectivity. Furthermore, the course teaches participants to systematically develop robust methods with DryLab4 by creating multidimensional models depicting the interaction of up to twelve of influential HPLC parameters, resulting in better communication with regulatory agencies and faster market entry for new drugs.

A part of this course is devoted to the topic Quality by Design in UHPLC method development. UHPLC users want to understand the QbD framework and how it relates to UHPLC method development processes, especially in regards to the submission of new drug applications. Analytical QbD is a modern concept for assuring the quality of a product, and is recommended by regulatory authorities like the FDA. The QbD approach requires a systematic study of the most important factors influencing the quality of a product, and can be successfully adopted into UHPLC method development using DryLab4 software. The course focuses on new approaches for visualizing the so-called “Design Space”, with the goal of gaining more flexibility in routine HPLC applications.


NEW: Method Development for the Separation of Therapeutic Proteins (Biopolymers) – 2 Days

This course gives an extensive training on HPLC (UHPLC) method development for the separation of therapeutic proteins. The fundamentals of reversed-phase (RP), ion-exchange (IEX), hydrophobic interaction (HI) and size-exclusion (SE) chromatography are explained and discussed. Several examples on monoclonal antibodies (mAbs) and related products (such as antibody-drug conjugates /ADCs/) are presented. 

MAbs and related therapeutics currently account for global sales of ≥USD 50 billion and are starting to receive competition from biosimilar incomes. Most pharmaceutical companies have entered the rapidly growing biosimilar market. Therefore, the appropriate and detailed analysis of biopharmaceuticals at different levels (top-down, middle-down and bottom-up) is demanded by the authorities.

Participants will learn the different two- and three-dimensional (3D) optimization models for all the above mentioned chromatographic modes. Fast and efficient method adjustment, transfer and robustness testing are also demonstrated.

UPCOMING COURSES

DryLab4

25.09  -  27.09.2017

Maritim proArte Hotel

Berlin, Germany

DryLab4

19.03  -  21.03.2018

Maritim proArte Hotel

Berlin, Germany

Separation of Biopolymers

03.07  -  04.07.2017

Maritim proArte Hotel

Berlin, Germany

Separation of Biopolymers

11.12  -  12.12.2017

Maritim proArte Hotel

Berlin, Germany

Method Development Services

Do you have a complex mixture and need an HPLC method immediately? The method needs to be robust and economical, with a short run time, but you anticipate weeks or even months of work on this task? Resources are tied up, and other projects must wait while valuable time is wasted?

If this sounds familiar, we have a solution! Simply send us your input runs, and we will develop a state-of-the-art DryLab method from our laboratory in Berlin.

We Deliver

  • All neccessary peak tracking
  • Development of a DryLab model
  • Proof of method robustness
  • A comprehensive method report

Contact us

Contact us to discuss your project. We will gladly consider other options and possible approaches.


Software Maintenance Services

We offer software maintenance, which includes: 

  • Support service for technical and chemical issues during method development
  • Analytical QbD consultation and advice
  • Software updates
  • Discounted rates for DryLab courses

Please contact us for more information.