Literature

You are here:

Literature

So far, more than 260 peer reviewed papers have been published on the application of DryLab – a complete list of which you can find here.

DryLab draws on the philosophy described in the three most famous Solvophobic Theory papers I, II, III of Csaba Horváth, which were developed in the years 1975-1977 at Yale University (see also literature by Dr. Imre Molnár).

Read more about the Fundamentals of DryLab and its History.

Simultaneous variation of temperature and gradient steepness for reversed-phase high-performance liquid chromatography method development: II. The use of further changes in conditions

J.W Dolan, L.R Snyder, D.L Saunders, L Van Heukelem
J. Chromatogr. A, 803, 1–2, 33–50 (1998), DOI: 10.1016/S0021-9673(97)01294-6

Keywords: Temperature effects, Gradient elution, Optimization, Method development, Computer simulation, Mobile phase composition, pH effects, Acrylate monomers, Fatty acid methyl esters, Steroids, Algal pigments, Benzoic acids, Anilines

http://www.sciencedirect.com/science/article/pi...

The preceding paper (Part I) suggests that simply optimizing temperature and gradient steepness will often provide an adequate reversed-phase HPLC separation. In some cases, however, this procedure will prove unsuccessful, and then further method-development experiments (involving change in other separation conditions) will be required. One strategy is to change a variable other than temperature or gradient steepness, followed by re-optimization of the latter two variables. The present paper examines the application of this approach with the aid of computer simulation to several samples.

The Linear-Solvent-Strength Model of Gradient Elution

L.R. Snyder, J.W. Dolan
Adv. Chromatogr., 38, 157–160 (1998)

A Computer-Assisted Strategy for HPLC Method Development. II. Simultaneous Changes in Temperature and Gradient Steepness Combined with Change in One or More Other Variables

J.W Dolan, L.R Snyder, D.L Saunders, L Van Heukelem
J. Chromatogr. A, 803 (1998)

Maintaining fixed band spacing when changing column dimensions in gradient elution

J.W Dolan, L.R Snyder
J. Chromatogr. A, 799, 1–2, 21–34 (1998)

Keywords: Gradient elution, Computer simulation, Column dimensions, Band spacing, Selectivity

http://www.sciencedirect.com/science/article/pi...

In gradient elution separations, it may be required to change either column length (to increase resolution or shorten run time) or column diameter (for an increase in sensitivity or for preparative separations). In either of these changes of column dimensions, it is usually desired to maintain the same relative band spacing (selectivity), so as to increase resolution in proportion to (column plate number)1/2 when increasing column length, or to maintain constant resolution when changing column diameter. Changes in band spacing as a result of change in column size are of special concern when developing procedures for preparative chromatography under gradient conditions.

Validation of Robust Chromatography Methods Using Computer-Assisted Method Development for Quality Control II

Imre Molnár
LCGC, 10, 1, 32 (1997)

Computer-Assisted Separation by HPLC with Diode Array Detection and Quantitative Determination of Furanocoumarins from Archangelica Officinalis

W. Markowski, K.L. Czapinska
Chem. Anal. (Warsaw), 42, 353 (1997)

BACK 1 ...

... 46 NEXT