MOLNÁR-INSTITUTE sharing streamlined Design Space modelling approaches with HPLC 2023 symposium
The Molnár-Institute for Applied Chromatography will again be a high-profile presence at the 2023 International Symposium on High Performance Liquid Phase Separations (HPLC 23), on its return to Germany.
The Molnár-Institute stand at Booth A2 in the Exhibition Zone at the Düsseldorf CCD Conference Center will present the organization’s revolutionary DryLab®4 separation modelling software that improves the efficiency and success of modern high-performance liquid chromatography (HPLC) through method development, as well as its various leading-edge learning programs.
Molnár-Institute team will be represented by Dr. Imre Molnár (President), Dr. Hans-Jürgen Rieger (Vice President Product Management), Dr. Markus Molnár (Business Strategy) and Mr. Arnold Zöldhegyi (Application Specialist).
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MOLNÁR-INSTITUTE to present LC Design Space applications at EAS 2022
Design Space analysis is key to rationalizing method and DryLab4 is one of the few tools in the world that by its design concept, will in that regard fully comply with ICH Q14 requirements. Being able to illuminate a total DS that comprises of more than a million modelled workpoints or method-parameter combinations, DryLab has repeatedly proven it's potential to revolutionize pharmaceutical chemistry and research.
Live demonstrations of DryLab4 will focus on the ability of its newly added interface with the Waters Empower™ platform to develop on-point HPLC methods faster than ever before by speeding up HPLC Design Space (DS) Modeling and using 3D visualization to gain deeper understanding of chromatography separations, allowing more robust and faster HPLC method development.
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MOLNÁR-INSTITUTE to present new enhanced chromatography modeling technique at ISC 2022
Regulatory intentions to move the industry towards a more risk-, and science-based decision-making process are clearly shown in a recently published ICH Q14 draft. Design Space Modeling effectively expands the chromatographer’s skills in his quantitative analytical work and can be implemented on a daily basis.
MOLNÁR-INSTITUTE for Applied Chromatography will return to ISC 2022 international symposium for chromatography with powerful enhancements to its DryLab®4 Automation and advanced HPLC modeling software. At this great international HPLC event, an efficient and uncomplicated development strategy for comparing multifactorial Design Spaces on an every-day basis will be introduced and demonstrated.
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MOLNÁR-INSTITUTE highlights ICH Q14's challenges to High Performance Liquid Chromatography
MOLNÁR-INSTITUTE for Applied Chromatography has identified the recently published International Council for Harmonization's ICH Q14 Quality Guideline as a potential «game changer» for the science of biochemical analysis.
The Q14 guideline not only demands researchers to describe methods and show their robustness, but also recommends that they provide rationale for choosing that method in the first place and how it was developed in that particular way.
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DryLab's Empower Automation running at Pannonian University
MOLNÁR-INSTITUTE has rolled out its new DryLab/Empower-Automation Module to facilitate and vastly economize University of Pannonia's Covid-19 research. Professor András Guttman and Assistant Professor Evelin Farsang will benefit from the seamless connection of DryLab method modeling software and Empower CDS for first-principles driven analytical procedure development. Furthermore, adding Waters' proprietary QDa MS to the ACQUITY UPLC I-Class will allow using four new power tools in DryLab's peak identification and tracking: (1) simple identification of substances per base peak values, (2) selected ion monitoring, (3) mass spectra at a certain retention time, and an intelligent auto-tracking by masses functionality.
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Another Peer-Reviewed Application Using Drylab: Separating Glycoproteins (Glajch, 2020)
A Novel Approach to Glycan Method Development for Biotherapeutics using Superficially Porous Particle Technology: Another DryLab application on a comprehensive study helped develop two methods for separation and profiling of 13 glycoproteins. The 2D model was done with 4 scouting runs only, and helped optimize the methods suitable for monitoring and control during process development or final manufacturing.
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Oral Presentation at Virtual 2020 EAS
Molnár-Institute presents an oral lecture on Automated Development of a Design Space using Chromatographic Modeling Software to Accommodate a Range of Complex OTC Drug Products.
The lecture to be available on-demand until 31 December 2020.
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Strategic cooperation between MI and Pannonian University
On the occasion of the launch of a strategic cooperation between Molnár-Institute for Applied Chromatography in Berlin and Professor András Guttman, Pannonian University of Veszprém, the renowned German research institute grants the university access to the DryLab® software it develops.
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Molnár-Institute invites you to join our intensive DryLab®4 Training for UHPLC Method Development
Molnár-Institute will be hosting three days of intensive DryLab HPLC method development training in Berlin, Germany.
The event will take place from 19-21 March 2018.
This course provides extensive training on UHPLC method modeling using the DryLab4 software package. Participants learn our comprehensive approach to method development, starting with basic one-dimensional model calculations and continuing through multi-dimensional (3D) model optimizations.
Part of this course is devoted to the topic of Quality by Design (QbD) in UHPLC method development.
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DryLab®-assisted HILIC-separation of mAb's
In a recent publication, Balázs Bobály and his colleagues successfully demonstrated the HILIC-separation of a complex mixture of monoclonal antibodies. This was done by using HPLC-modeling software, in this case DryLab®4.
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Analysis of mAb's and ADC's
The team of Szabolcs Fekete and Davy Guillarme (Univ. Geneva, CH) contributed two new papers about the analysis of monoclonal antibodies (mAb’s) and conjugated molecules in Journal of Pharmaceutical and Biomedical Analysis. The technique applied was Hydrophobic Interaction Chromatography (HIC), which seems to work with antibody-drug-conjugates (ADC’s) with great success, opening up new capabilities in the field of effective cancer treatment. The best separation conditions were found fast with the newest DryLab4-HPLC-method development software, developed by Molnár-Institute, Berlin. Analysis time was typically less than 10 min, method development time is approximately half a day.
Read more in our literature section!
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Dr. Imre Molnár receives Csaba Horváth Memorial Award
Dr. Imre Molnár is a proud recipient of the Csaba Horváth Memorial Award, presented by the Hungarian Society of Separation Sciences in 2005.
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