Leading Roles at ISSS 2024 Symposium in Messina, Italy
The MOLNÁR-INSTITUTE for Applied Chromatography will be returning as a prominent presenter at the 28th International Symposium on Separation Sciences (ISSS 2024), this time to be hosted in Messina, Sicily.
The MOLNÁR-INSTITUTE is both a Gold Sponsor of the meeting and a leading contributor to the conference program.
During the late afternoon of Day 1, MOLNÁR-INSTITUTE President Dr. Imre Molnár will conclude the Csaba Horváth Memorial Session by paying tribute to the hungarian scientist as the father of Reversed Phase Chromatography (RPC), enabling a revolution in life science (September 22, 17:00-18:20, Vittorio Ricevuto Room).
Dr. Molnár will also chair the Day 3 Scientific Session 12, that will feature lectures on diverse topics that include Multidimensional Preparative Gas Chromatography (GC) for sustainable isolation of target analytes, Developing Fuel Property Prediction Models using Comprehensive 2D Gas Chromatography, and selective isolation of chemicals by a customized GC×GC setup.
Software DryLab contributes strongly to the "green chromatography movement", as a model chromatogram is produced in one second, allowing great saving of organic eluents.
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Gold Sponsor of Hungarian Biochemical conference
MOLNÁR-INSTITUTE for Applied Chromatography will be a prominent presence at the upcoming annual meeting of the Hungarian Biochemical Society, HBS 2024, in Budapest. As a Gold Sponsor of the event, MOLNÁR-INSTITUTE is proud to support this gathering, which will be hosted on the campus of Eötvös Loránd University—one of Hungary’s leading research institutions.
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ACHEMA 2024: Discover DryLab®4 HPLC Modeling Software
Meet the expert team from Molnár-Institute at Booth D30, located in the Laboratory and Analytical Techniques Zone within Hall 12 of the Messe center in Frankfurt-am-Main. Molnár-Institute for Applied Chromatography will be showcasing its latest advancements, including the integration of cutting-edge analytical solutions into DryLab®4 advanced liquid chromatography modeling software, at the upcoming ACHEMA 2024 expo for the chemical engineering and process industries.
Molnár team will share recent advancements and offer invaluable technical insight into their software support for implementing analytical Quality by Design (AQbD) principles. Modeling examples using DryLab®4 will cover a range of use cases, including dynamic presentations on automated features that drive multiple levels of the software’s AQbD workflow. Additionally, the team will demonstrate multi-attribute modeling capabilities, allowing for the customization of Analytical Target Profile (ATP) requirements. Attendees can also explore in silico options for real-time quantification of robust separation performance and engage in systematic comparisons of multidimensional design spaces.
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100th Citation of Our Study of Using Design Spaces in HPLC
Our scientific study «Aspects of the ‘Design Space’ in high pressure liquid chromatography method development» by H.J. Rieger, I. Molnár and K. Monks, which was published in Journal of Chromatography A 1217 (2010) 193-200, was cited more than 100 times.
The publication describes a multifactorial optimization of four critical HPLC method parameters: gradient time (tG), temperature (T), pH and ternary composition (B1:B2). The approach, implemented in DryLab®2010, enabled the scientists to effectively separate 14 peaks with a run time of under 20 minutes while demonstrating robustness to critical parameters. The methodology aligned with Quality by Design (QbD) principles and established a Design Space identifying multiple robust working conditions of HPLC methods. Further benefits of DryLab Design Space Modeling lied in the efficiency it brought to routine method development and the compliance it had with regulatory demands.
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2023 Nobel Prize in Medicine
On October 30th 2023, Imre Molnár met Katalin Karikó in Berlin. Katalin was recently awarded the the 2023 Nobel Prize in Physiology or Medicine together with Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
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Strategic collaboration with CycloLab Ltd. opens up new possibilities of reversed-phase modeling of cyclodextrins · HPLC 2023
The scientific study illustrates why a systematic modeling approach to contextualize data and optimize critical method parameters is essential for better understanding the complex nature and chromatographic behavior of regioisomers of Di-OH-SGM. This approach was used to develop a simple and cost-effective RP-HPLC application for separating these regioisomers, which is required for the qualification of the synthesized Di-OH-SGM material. The results of this work can be applied in various fields, including pharmaceuticals, biotechnology, and materials science.
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MOLNÁR-INSTITUTE to present LC Design Space applications at EAS 2022
Design Space analysis is key to rationalizing method and DryLab4 is one of the few tools in the world that by its design concept, will in that regard fully comply with ICH Q14 requirements. Being able to illuminate a total DS that comprises of more than a million modelled workpoints or method-parameter combinations, DryLab has repeatedly proven it's potential to revolutionize pharmaceutical chemistry and research.
Live demonstrations of DryLab4 will focus on the ability of its newly added interface with the Waters Empower™ platform to develop on-point HPLC methods faster than ever before by speeding up HPLC Design Space (DS) Modeling and using 3D visualization to gain deeper understanding of chromatography separations, allowing more robust and faster HPLC method development.
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MOLNÁR-INSTITUTE to present new enhanced chromatography modeling technique at ISC 2022
Regulatory intentions to move the industry towards a more risk-, and science-based decision-making process are clearly shown in a recently published ICH Q14 draft. Design Space Modeling effectively expands the chromatographer’s skills in his quantitative analytical work and can be implemented on a daily basis.
MOLNÁR-INSTITUTE for Applied Chromatography will return to ISC 2022 international symposium for chromatography with powerful enhancements to its DryLab®4 Automation and advanced HPLC modeling software. At this great international HPLC event, an efficient and uncomplicated development strategy for comparing multifactorial Design Spaces on an every-day basis will be introduced and demonstrated.
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MOLNÁR-INSTITUTE highlights ICH Q14's challenges to High Performance Liquid Chromatography
MOLNÁR-INSTITUTE for Applied Chromatography has identified the recently published International Council for Harmonization's ICH Q14 Quality Guideline as a potential «game changer» for the science of biochemical analysis.
The Q14 guideline not only demands researchers to describe methods and show their robustness, but also recommends that they provide rationale for choosing that method in the first place and how it was developed in that particular way.
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DryLab's Empower Automation running at Pannonian University
MOLNÁR-INSTITUTE has rolled out its new DryLab/Empower-Automation Module to facilitate and vastly economize University of Pannonia's Covid-19 research. Professor András Guttman and Assistant Professor Evelin Farsang will benefit from the seamless connection of DryLab method modeling software and Empower CDS for first-principles driven analytical procedure development. Furthermore, adding Waters' proprietary QDa MS to the ACQUITY UPLC I-Class will allow using four new power tools in DryLab's peak identification and tracking: (1) simple identification of substances per base peak values, (2) selected ion monitoring, (3) mass spectra at a certain retention time, and an intelligent auto-tracking by masses functionality.
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Another Peer-Reviewed Application Using Drylab: Separating Glycoproteins (Glajch, 2020)
A Novel Approach to Glycan Method Development for Biotherapeutics using Superficially Porous Particle Technology: Another DryLab application on a comprehensive study helped develop two methods for separation and profiling of 13 glycoproteins. The 2D model was done with 4 scouting runs only, and helped optimize the methods suitable for monitoring and control during process development or final manufacturing.
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Oral Presentation at Virtual 2020 EAS
Molnár-Institute presents an oral lecture on Automated Development of a Design Space using Chromatographic Modeling Software to Accommodate a Range of Complex OTC Drug Products.
The lecture to be available on-demand until 31 December 2020.
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Strategic cooperation between MI and Pannonian University
On the occasion of the launch of a strategic cooperation between Molnár-Institute for Applied Chromatography in Berlin and Professor András Guttman, Pannonian University of Veszprém, the renowned German research institute grants the university access to the DryLab® software it develops.
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Molnár-Institute invites you to join our intensive DryLab®4 Training for UHPLC Method Development
Molnár-Institute will be hosting three days of intensive DryLab HPLC method development training in Berlin, Germany.
The event will take place from 19-21 March 2018.
This course provides extensive training on UHPLC method modeling using the DryLab4 software package. Participants learn our comprehensive approach to method development, starting with basic one-dimensional model calculations and continuing through multi-dimensional (3D) model optimizations.
Part of this course is devoted to the topic of Quality by Design (QbD) in UHPLC method development.
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DryLab®-assisted HILIC-separation of mAb's
In a recent publication, Balázs Bobály and his colleagues successfully demonstrated the HILIC-separation of a complex mixture of monoclonal antibodies. This was done by using HPLC-modeling software, in this case DryLab®4.
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Analysis of mAb's and ADC's
The team of Szabolcs Fekete and Davy Guillarme (Univ. Geneva, CH) contributed two new papers about the analysis of monoclonal antibodies (mAb’s) and conjugated molecules in Journal of Pharmaceutical and Biomedical Analysis. The technique applied was Hydrophobic Interaction Chromatography (HIC), which seems to work with antibody-drug-conjugates (ADC’s) with great success, opening up new capabilities in the field of effective cancer treatment. The best separation conditions were found fast with the newest DryLab4-HPLC-method development software, developed by Molnár-Institute, Berlin. Analysis time was typically less than 10 min, method development time is approximately half a day.
Read more in our literature section!
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New Knowledge Management Module
DryLab Knowledge Management offers comprehensive method documentation for better knowledge sharing. It automatically collects all relevant method data directly from DryLab and offers you a platform for comments and the justification of method criteria.
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European Pharmaceutical Review Interviews Molnár-Institute at AAPS
Company President, Dr. Imre Molnár, speaks with Freddy White about the history of DryLab and how the software enables users in the pharmaceutical industry to conform to the FDA's analytical Quality by Design (QbD) requirements during HPLC method development.
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Dr. Imre Molnár receives Csaba Horváth Memorial Award
Dr. Imre Molnár is a proud recipient of the Csaba Horváth Memorial Award, presented by the Hungarian Society of Separation Sciences in 2005.
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